non-aqueous electromigration analysis of some degradation products of carvedilol

Authors

abolghasem jouyban adrug applied research center and faculty of pharmacy, tabriz university of medical sciences, tabriz 51664, iran.

mohammad hasanzadeh bliver and gastrointestinal diseases research center, tabriz university of medical sciences, tabriz 51664, iran.

nasrin shadjou cbiochemistry lab, pasteur institute of iran, tehran, iran.

abstract

a capillary electrophoresis method was used for assay of some degradation products of carvedilol. the optimized parameters were as; running buffer 80 mm acetate dissolved in methanol/ethanol mixture (65:35 v/v), applied voltage of 19 kv, temperature is 20 ºc and the wavelength range of 200-350 nm. the results indicate that the proposed ce method could effectively separate carvedilol from its degradation products and can be employed as a stability indicating assay method. in addition, the presence of a new unknown degradation product was discovered by this method. in addition, ce behaviour of carvedilol in photo/force degradation conditions gave valuable information concerning the dissimilarities of their ionization. results indicated that the ce proposed method can be used for the determination of carvedilol in human serum. finally, accuracy of the proposed method was established by recovery experiments from spiked human serum samples.

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Journal title:
iranian journal of pharmaceutical research

جلد ۱۳، شماره ۲، صفحات ۴۷۱-۴۸۶

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